AustralieFrV1, PubMed, Curation, bibRecord, 002F26

Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.

Identifieur interne : 002F26 ( PubMed/Curation ); précédent : 002F25; suivant : 002F27

Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.

Auteurs : Sabine Dittrich [Royaume-Uni] ; Sayaphet Rattanavong ; Sue J. Lee [Thaïlande] ; Phonepasith Panyanivong ; Scott B. Craig [Australie] ; Suhella M. Tulsiani [Danemark] ; Stuart D. Blacksell [Thaïlande] ; David A B. Dance [Royaume-Uni] ; Audrey Dubot-Pérès [France] ; Amphone Sengduangphachanh ; Phonelavanh Phoumin ; Daniel H. Paris [Thaïlande] ; Paul N. Newton [Royaume-Uni]

Source :

The Lancet. Global health [ 2214-109X ] ; 2015.

RBID : pubmed:25617190

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Encéphalite (microbiologie), Encéphalite (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Laos (épidémiologie), Leptospira (isolement et purification), Mâle, Méningite (microbiologie), Méningite (épidémiologie), Nourrisson, Nouveau-né, Orientia tsutsugamushi (isolement et purification), Rickettsia (isolement et purification), Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
MESH :
- isolement et purification : Leptospira, Orientia tsutsugamushi, Rickettsia.
- microbiologie : Encéphalite, Méningite.
- épidémiologie : Encéphalite, Laos, Méningite.
- Adolescent, Adulte, Adulte d'âge moyen, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Encephalitis (epidemiology), Encephalitis (microbiology), Female, Humans, Infant, Infant, Newborn, Laos (epidemiology), Leptospira (isolation & purification), Male, Meningitis (epidemiology), Meningitis (microbiology), Middle Aged, Orientia tsutsugamushi (isolation & purification), Prospective Studies, Rickettsia (isolation & purification), Young Adult.
MESH :
- geographic , epidemiology : Laos.
- epidemiology : Encephalitis, Meningitis.
- isolation & purification : Leptospira, Orientia tsutsugamushi, Rickettsia.
- microbiology : Encephalitis, Meningitis.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Prospective Studies, Young Adult.

Abstract

Scrub typhus (caused by Orientia tsutsugamushi), murine typhus (caused by Rickettsia typhi), and leptospirosis are common causes of febrile illness in Asia; meningitis and meningoencephalitis are severe complications. However, scarce data exist for the burden of these pathogens in patients with CNS disease in endemic countries. Laos is representative of vast economically poor rural areas in Asia with little medical information to guide public health policy. We assessed whether these pathogens are important causes of CNS infections in Laos.

DOI: 10.1016/S2214-109X(14)70289-X
PubMed: 25617190

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Sayaphet Rattanavong

<affiliation><nlm:affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</nlm:affiliation>
<wicri:noCountry code="subField">Lao PDR</wicri:noCountry>
</affiliation>

Phonepasith Panyanivong

<affiliation><nlm:affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</nlm:affiliation>
<wicri:noCountry code="subField">Lao PDR</wicri:noCountry>
</affiliation>

Amphone Sengduangphachanh

<affiliation><nlm:affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</nlm:affiliation>
<wicri:noCountry code="subField">Lao PDR</wicri:noCountry>
</affiliation>

Phonelavanh Phoumin

<affiliation><nlm:affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</nlm:affiliation>
<wicri:noCountry code="subField">Lao PDR</wicri:noCountry>
</affiliation>

Le document en format XML

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</affiliation>
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<author><name sortKey="Newton, Paul N" sort="Newton, Paul N" uniqKey="Newton P" first="Paul N" last="Newton">Paul N. Newton</name>
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<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea>
</affiliation>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of the Sunshine Coast, Faculty of Science Health, Education and Engineering, Sippy Downs, Australia; Queensland Health Forensic and Scientific Service, WHO Collaborating Centre for Reference and Research on Leptospirosis, Brisbane</wicri:regionArea>
</affiliation>
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<author><name sortKey="Tulsiani, Suhella M" sort="Tulsiani, Suhella M" uniqKey="Tulsiani S" first="Suhella M" last="Tulsiani">Suhella M. Tulsiani</name>
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<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Queensland Health Forensic and Scientific Service, WHO Collaborating Centre for Reference and Research on Leptospirosis, Brisbane, Australia; Copenhagen Centre for Disaster Research Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen</wicri:regionArea>
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<author><name sortKey="Blacksell, Stuart D" sort="Blacksell, Stuart D" uniqKey="Blacksell S" first="Stuart D" last="Blacksell">Stuart D. Blacksell</name>
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<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dance, David A B" sort="Dance, David A B" uniqKey="Dance D" first="David A B" last="Dance">David A B. Dance</name>
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<country xml:lang="fr">Royaume-Uni</country>
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</affiliation>
</author>
<author><name sortKey="Dubot Peres, Audrey" sort="Dubot Peres, Audrey" uniqKey="Dubot Peres A" first="Audrey" last="Dubot-Pérès">Audrey Dubot-Pérès</name>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Sengduangphachanh, Amphone" sort="Sengduangphachanh, Amphone" uniqKey="Sengduangphachanh A" first="Amphone" last="Sengduangphachanh">Amphone Sengduangphachanh</name>
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<author><name sortKey="Phoumin, Phonelavanh" sort="Phoumin, Phonelavanh" uniqKey="Phoumin P" first="Phonelavanh" last="Phoumin">Phonelavanh Phoumin</name>
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<author><name sortKey="Paris, Daniel H" sort="Paris, Daniel H" uniqKey="Paris D" first="Daniel H" last="Paris">Daniel H. Paris</name>
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<country xml:lang="fr">Thaïlande</country>
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</affiliation>
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<author><name sortKey="Newton, Paul N" sort="Newton, Paul N" uniqKey="Newton P" first="Paul N" last="Newton">Paul N. Newton</name>
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<series><title level="j">The Lancet. Global health</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Encephalitis (epidemiology)</term>
<term>Encephalitis (microbiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Laos (epidemiology)</term>
<term>Leptospira (isolation & purification)</term>
<term>Male</term>
<term>Meningitis (epidemiology)</term>
<term>Meningitis (microbiology)</term>
<term>Middle Aged</term>
<term>Orientia tsutsugamushi (isolation & purification)</term>
<term>Prospective Studies</term>
<term>Rickettsia (isolation & purification)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Encéphalite (microbiologie)</term>
<term>Encéphalite (épidémiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Laos (épidémiologie)</term>
<term>Leptospira (isolement et purification)</term>
<term>Mâle</term>
<term>Méningite (microbiologie)</term>
<term>Méningite (épidémiologie)</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Orientia tsutsugamushi (isolement et purification)</term>
<term>Rickettsia (isolement et purification)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études prospectives</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Laos</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Encephalitis</term>
<term>Meningitis</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Leptospira</term>
<term>Orientia tsutsugamushi</term>
<term>Rickettsia</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Leptospira</term>
<term>Orientia tsutsugamushi</term>
<term>Rickettsia</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Encéphalite</term>
<term>Méningite</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Encephalitis</term>
<term>Meningitis</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Encéphalite</term>
<term>Laos</term>
<term>Méningite</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prospective Studies</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études prospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Scrub typhus (caused by Orientia tsutsugamushi), murine typhus (caused by Rickettsia typhi), and leptospirosis are common causes of febrile illness in Asia; meningitis and meningoencephalitis are severe complications. However, scarce data exist for the burden of these pathogens in patients with CNS disease in endemic countries. Laos is representative of vast economically poor rural areas in Asia with little medical information to guide public health policy. We assessed whether these pathogens are important causes of CNS infections in Laos.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25617190</PMID>
<DateCreated><Year>2015</Year>
<Month>01</Month>
<Day>24</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>09</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2214-109X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>3</Volume>
<Issue>2</Issue>
<PubDate><Year>2015</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>The Lancet. Global health</Title>
<ISOAbbreviation>Lancet Glob Health</ISOAbbreviation>
</Journal>
<ArticleTitle>Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.</ArticleTitle>
<Pagination><MedlinePgn>e104-12</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S2214-109X(14)70289-X</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S2214-109X(14)70289-X</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Scrub typhus (caused by Orientia tsutsugamushi), murine typhus (caused by Rickettsia typhi), and leptospirosis are common causes of febrile illness in Asia; meningitis and meningoencephalitis are severe complications. However, scarce data exist for the burden of these pathogens in patients with CNS disease in endemic countries. Laos is representative of vast economically poor rural areas in Asia with little medical information to guide public health policy. We assessed whether these pathogens are important causes of CNS infections in Laos.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Between Jan 10, 2003, and Nov 25, 2011, we enrolled 1112 consecutive patients of all ages admitted with CNS symptoms or signs requiring a lumbar puncture at Mahosot Hospital, Vientiane, Laos. Microbiological examinations (culture, PCR, and serology) targeted so-called conventional bacterial infections (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, S suis) and O tsutsugamushi, Rickettsia typhi/Rickettsia spp, and Leptospira spp infections in blood or cerebrospinal fluid (CSF). We analysed and compared causes and clinical and CSF characteristics between patient groups.</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">1051 (95%) of 1112 patients who presented had CSF available for analysis, of whom 254 (24%) had a CNS infection attributable to a bacterial or fungal pathogen. 90 (35%) of these 254 infections were caused by O tsutsugamushi, R typhi/Rickettsia spp, or Leptospira spp. These pathogens were significantly more frequent than conventional bacterial infections (90/1051 [9%] vs 42/1051 [4%]; p<0·0001) by use of conservative diagnostic definitions. CNS infections had a high mortality (236/876 [27%]), with 18% (13/71) for R typhi/Rickettsia spp, O tsutsugamushi, and Leptospira spp combined, and 33% (13/39) for conventional bacterial infections (p=0·076).</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Our data suggest that R typhi/Rickettsia spp, O tsutsugamushi, and Leptospira spp infections are important causes of CNS infections in Laos. Antibiotics, such as tetracyclines, needed for the treatment of murine typhus and scrub typhus, are not routinely advised for empirical treatment of CNS infections. These severely neglected infections represent a potentially large proportion of treatable CNS disease burden across vast endemic areas and need more attention.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Wellcome Trust UK.</AbstractText>
<CopyrightInformation>Copyright © 2015 Dittrich et al. Open Access article published under the terms of CC BY. Published by .. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dittrich</LastName>
<ForeName>Sabine</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rattanavong</LastName>
<ForeName>Sayaphet</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Sue J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Panyanivong</LastName>
<ForeName>Phonepasith</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Craig</LastName>
<ForeName>Scott B</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>University of the Sunshine Coast, Faculty of Science Health, Education and Engineering, Sippy Downs, Australia; Queensland Health Forensic and Scientific Service, WHO Collaborating Centre for Reference and Research on Leptospirosis, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tulsiani</LastName>
<ForeName>Suhella M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Queensland Health Forensic and Scientific Service, WHO Collaborating Centre for Reference and Research on Leptospirosis, Brisbane, Australia; Copenhagen Centre for Disaster Research Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Blacksell</LastName>
<ForeName>Stuart D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dance</LastName>
<ForeName>David A B</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubot-Pérès</LastName>
<ForeName>Audrey</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK; UMR_D 190 "Emergence des Pathologies Virales", Aix-Marseille University, IRD French Institute of Research for Development, EHESP French School of Public Health, Marseille, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sengduangphachanh</LastName>
<ForeName>Amphone</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Phoumin</LastName>
<ForeName>Phonelavanh</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paris</LastName>
<ForeName>Daniel H</ForeName>
<Initials>DH</Initials>
<AffiliationInfo><Affiliation>Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Newton</LastName>
<ForeName>Paul N</ForeName>
<Initials>PN</Initials>
<AffiliationInfo><Affiliation>Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, University of Oxford, Oxford, UK. Electronic address: paul@tropmedres.ac.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Lancet Glob Health</MedlineTA>
<NlmUniqueID>101613665</NlmUniqueID>
<ISSNLinking>2214-109X</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004660" MajorTopicYN="N">Encephalitis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007812" MajorTopicYN="N" Type="Geographic">Laos</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007919" MajorTopicYN="N">Leptospira</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008581" MajorTopicYN="N">Meningitis</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012285" MajorTopicYN="N">Orientia tsutsugamushi</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012281" MajorTopicYN="N">Rickettsia</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
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Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.

Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.

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